However, the exact timeline also depends on the type of rash you have, as well as the severity. People who take ELIQUIS, and have medicine injected into their spinal or epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Specifically, Eliquis is approved for use in adults to: Depending on the reason for taking Eliquis, you may take it short term or long term. If youd like to learn more about Eliquis, talk with your doctor or pharmacist. This can help to prevent blood clots. (2020). But kidney-related side effects were not commonly reported in studies of the drug. Eliquis has a boxed warning for this risk. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. This can lead to blood clots forming, which can travel to other parts of your body (such as the lungs or legs) or increase your risk for stroke. Depending on the severity of the reaction, drug rashes may not necessarily be a cause for worry. Please see U.S. Full Prescribing Information, including Boxed WARNINGS and MedicationGuide. As with many medications, higher dosages of Eliquis are more likely to cause side effects than lower dosages. You can then share this information with your doctor. What are the more common side effects of Eliquis? While any drug can cause a rash, certain types are more notorious for causing reactions. Possible serious side effects include bleeding or a reaction to ELIQUIS itself. All rights reserved. They can determine the best treatment plan for you. Both these effects of Eliquis can increase your risk of bleeding. [Text HELP to 69108 for help.] Certain drugs can make your skin extra sensitive to ultraviolet light, causing a subsequent itchy sunburn if you go outside without wearing sunscreen and protective clothing. No, its not known to. Keep all medications away from children and pets. Because its not known if breastfeeding while taking Eliquis is safe, its currently not recommended. The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. Discuss the risks and benefits with your doctor. Examples of these include kidney problems and bleeding problems, such as a bleeding stomach ulcer. Ask them what other medications may be better options for you. Note that if youre taking Eliquis when you go into labor, you may have a risk of spinal blood clots if you receive epidural anesthesia for pain relief. You may experience side effects during your treatment with Eliquis. Withdrawal symptoms are side effects that can occur if you stop taking a drug that your body relies on. Eliquis will likely make the bleeding worse. Liver problems. If it is near the time of the next dose, skip the missed dose. Your doctor may recommend stopping Eliquis temporarily before certain medical, surgical, or dental procedures. Weight gain wasnt reported in clinical trials of Eliquis. However, if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. About 1% of patients have allergic or hematologic adverse reactions to clopidogrel. * This clot may press on your spinal cord, which could cause long lasting or permanent paralysis. Most of the drugs side effects are mild. Eliquis can build up in your body if your liver isnt working properly. For more information about Eliquis, including details about its uses, see this in-depth article. Eliquis (apixaban) is a brand-name prescription medication. Due to this risk, your doctor may recommend stopping Eliquis at a certain time before your procedure to prevent bleeding. Some conditions may become worse when this drug is suddenly stopped. ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. Do not stop taking ELIQUIS without talking to the doctor who prescribed it to you. Last medically reviewed on August 29, 2022, Blood clots can form in many different parts of the body. ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. Tell your healthcare team about all the medicines you take, including any: During treatment, make sure you talk to your healthcare team before you begin to take any newmedication. Warfarin-induced skin necrosis refers to a rare condition in which there is paradoxical blood clotting. Eliquis comes with several warnings, which may affect whether the drug is a good treatment for your condition. Warfarin is an anticoagulant medicine (blood thinner). Bleeding problems. ELIQUIS is a prescription medicine used to: Reduce the risk of stroke and blood clots in people who have atrial fibrillation (AFib), a type of irregular heartbeat, not caused by a heart valve problem. However, these side effects werent reported in clinical trials of Eliquis. At first, you might notice your skin turns red and painful. If you have nosebleeds during your treatment with Eliquis, talk with your doctor. Call your doctor for medical advice about side effects. Learn more about some of the side effects that Eliquis may cause. These symptoms could be life threatening and require immediate medical care. Keep reading to learn more. Triple-positive antiphospholipid syndrome (APS). Try wearing loose clothing and reducing skin-to-skin friction in affected areas. Eliquis is used to treat and help prevent dangerous blood clots. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Learn more here. Stopping ELIQUIS increases your risk of having a stroke. What should I know regarding pregnancy, nursing and administering Eliquis to children or the elderly. If you have kidney problems, Eliquis may build up in your body. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS. Introduction: Rivaroxaban is a novel oral anticoagulant with several indications, one of which is for stroke prevention in nonvalvular atrial fibrillation. This medication can cause bleeding. If you have constipation or diarrhea with Eliquis, talk with your doctor. If you have a nosebleed, pinch the top of your nose tightly for 10 minutes to help stop the bleeding. This may include bleeding in organs such as the kidneys. The drug is available in strengths of 2.5 milligrams (mg) and 5 mg. Youll take Eliquis twice per day. We present a case of probable rivaroxaban-induced rash. This drug may not be the right treatment for you if you have certain medical conditions or other factors that affect your health. Boxed warnings are the most serious warnings from the FDA. The study is based on apixaban (the active ingredients of Eliquis). If youre concerned about the risk of side effects with the dosage of Eliquis your doctor has prescribed, talk with your doctor. However, your risk of this reaction tends to be higher at the start of taking a very high dose of a new blood thinner. While taking Eliquis, you should be extra careful with activities that could cause a cut, injury, or bleeding. Triple-positive antiphospholipid syndrome (APS). This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. These include antibiotics (especially penicillins and sulfa drugs), nonsteroidal anti-inflammatory drugs (NSAIDs), and antiseizure drugs. Dont stop taking Eliquis without first talking with your doctor. Eliquis can cause certain side effects, some of which are more common than others. Symptoms of serious bleeding may include: If you have symptoms of serious bleeding, call your doctor right away. You are about to leave the Bristol Myers Squibb and Pfizer ELIQUIS.com site. Blood clots block the blood vessels and cause necrosis, where an area of skin is destroyed. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements. You should always consult your doctor or another healthcare professional before taking any medication. Its recommended that you do not stop taking Eliquis without first talking with your doctor. These are not all of the possible side effects of ELIQUIS. To learn more, see the Side effects explained section below. To learn more about this side effect, see the Side effects explained section below. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. The two companies were testing Eliquis, which includes apixaban, an orally-taken inhibitor which blocks a key blood-clotting protein, reducing the risk of thrombin generation and blood clots. Mild side effects that have been reported with Eliquis include: bruising. Refill your prescription before you run out. For this reason,your doctor will likely not prescribe Eliquis. Call your doctor for medical advice about side effects. Get medical help right away if you have any of the following symptoms: Sudden chest pain or chest tightness Sudden swelling of your face or tongue Trouble breathing Wheezing What does Eliquis look like? You may have a raised risk of bleeding with Eliquis if you already have a bleeding problem and if you take Eliquis in combination with other drugs that affect blood clotting. Cellulitis may also occur on the arm, breast, abdomen, and other areas. Symptoms of overdose may include: bloody/black/tarry stools, pink/dark urine, unusual/prolonged bleeding. You should not do both. Talk with your doctor about the best treatment plan for you. Symptoms can be mild to serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. Established Eliquis (Apixaban) Side Effects Regardless of lawsuits, what we know is that apixaban has some pretty serious adverse effects. Ask your doctor what other medications may be better options for you. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. If you need a spinal procedure while taking Eliquis and youre concerned about the risk of spinal blood clots, talk with your doctor. Eliquis increases the risk of bleeding. Like most drugs, Eliquis can cause an allergic reaction in some people. If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time. Bristol Myers Squibb reserves the right to rescind, revoke, or amend the Program without notice. Another rare side effect of Eliquis is blood in the urine, which could be due to a kidney-related problem. Get answers to some frequently asked questions about the side effects of Eliquis. None of it's unbearable (yet). Serious side effects that have been reported with Eliquis include: * For more information about this side effect, see Side effect specifics below. To our knowledge, there is only one other reported case due to apixaban in the literature [ 1 ]. Properly discard this product when it is expired or no longer needed. risk of developing an epidural blood clot, To Reduce Stroke Risk Due to AFib Not Caused by, eligibility requirements and terms of use. The products discussed herein may have different product labeling in different countries. Eliquis works by reducing your bloods ability to form clots. Taking a blood thinner as part of your AFib treatment can reduce your risk of blood clots and stroke. Please see Full Prescribing Information, including Boxed WARNINGS and Medication Guide. Warfarin-induced skin necrosis affects one in every 10,000 patients prescribed warfarin. To learn more, see the Side effects explained section above. For people taking ELIQUIS (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Liver problems. Examples of commonly reported side effects of Eliquis include: * To learn more about this side effect, see the Side effects explained section below. If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. For more information, see the Side effect specifics section above. Examples of the blood clots Eliquis treats include deep vein thrombosis (DVT) and pulmonary embolism (PE). If youre concerned about kidney-related side effects occurring during Eliquis treatment, talk with your doctor or pharmacist. If youre taking Eliquis and need an epidural injection for pain relief during labor, you may have an increased risk of developing a spinal blood clot. If you have liver problems, tell your doctor before you start taking this drug. Ask your doctor or pharmacist about how much alcohol you may safely drink. Activation and first use of the Co-pay. Theproducts discussed herein may have different product labeling in different countries. This is to reduce your risk of bleeding. This rash may develop suddenly or within hours, but it can take up to several weeks in some cases. Apixaban is used to prevent serious blood clots from forming due to a certain irregular heartbeat (atrial fibrillation) or after hip/knee replacement surgery. If youve had an allergic reaction to Eliquis or any of its ingredients, your doctor will likely not prescribe Eliquis. Your doctor may switch the type of medication you use during pregnancy. Examples include certain azole antifungals (such as itraconazole, ketoconazole, posaconazole), conivaptan, HIV protease inhibitors (such as lopinavir), rifamycins (such as rifabutin), ritonavir, St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. They can then use this information to adjust your treatment plan if needed. However, some serious side effects are also possible. Is my risk of side effects increased due to other medications that Im taking? If any of these effects last or get worse, tell your doctor or pharmacist promptly. Do not double the dose to catch up. Drug rashes can appear as a variety of skin rashes, including pink to red bumps, hives, blisters, red patches, pus-filled bumps (pustules), or sensitivity to sunlight.