Existing investors that took part in the financing include MPM Capital Management, Binney Street Capital/Dana-Farber Cancer Institute and NextPoint founder Gordon Freeman, PhD. Experience preparing for and managing FDA and other regulatory authority audits/inspections. Requests may be made only once a year and are free of charge. Our team of proven drug developers is working closely with our renowned scientific founders to launch a new world of precision immuno-oncology. Press release content from Business Wire. Supply Chain Management Trainee Program, International YOU EXPRESSLY AGREE THAT USE OF THE WEBSITE AND RELATED CONTENT IS AT YOUR SOLE RISK. Japan or in any other jurisdiction in which such offer or solicitation is not authorized or to any Phone: +49 214 30 1, Mllerstrae 178 By clicking on the I AGREE button, I certify that I am not located About Sanofi VenturesSanofi Ventures is the corporate venture capital arm of Sanofi. interstate or foreign commerce, or of any facility of a national securities exchange of the United Order 2005 (the Order) or (ii) high net worth companies, and other persons to whom it may lawfully In addition, you may contact the relevant data protection authority in the EU Member State of your residence, place of work or of the alleged infringement. Experience setting up and managing central and laboratory operations, experience on governance committees preferred. CAMBRIDGE, Mass., February 21, 2023 -- ( BUSINESS WIRE )-- NextPoint Therapeutics, a biotechnology company developing a new world of precision immuno-oncology, announced today the appointment of. NextPoint Therapeutics has announced an $80 million Series B funding round to move two lead precision immuno-oncology programs into the clinic. Forward-Looking StatementsThis release may contain forward-looking statements based on current assumptions and forecasts made by Bayer management. Avoid Counterfeits, Bayers role in Management, Bayer 50 accepted by any such use, means, instrumentality or facility or from within the United States. Freemans and Zangs independent discovery and characterization of the HHLA2 pathway formed the basis of the NextPoint approach. Prospectus Directive), as permitted under the Prospectus Directive, or. Contact Us - Nextpoint Questions about Nextpoint? Education, Health, Alternatively, users can deactivate cookies from third-party providers by going to the network advertising initiatives deactivation page (link:https://optout.networkadvertising.org/?c=1). 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INFORMATION FROM CHILDREN UNDER 13 YEARS OF AGE. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T cell function. find Bayer country websites and Bhatt RS, Berjis A, Konge JC, et al. About BayerBayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Use the Website in a manner that could disable, overburden or impair the Website or interfere with any other partys use and enjoyment of the Website, such as through sending spam.. on jurisdictions. NextPoint is building a deep understanding of the HHLA2 tumor-specific immune-escape mechanism, with the ultimate goal of establishing standalone treatments in cancers with high HHLA2 expression, said Detlev Biniszkiewicz, PhD, Chief Executive Officer of NextPoint Therapeutics. Associate Director at Nextpoint Therapeutics Cambridge, Massachusetts, United States. Zhao R, Chinai JM, Buhl S, et al. Higher wind gusts possible.. +49 2173 380. 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Our innovative approach integrates foundational science with a defined clinical biomarker to deliver a new class of monotherapies for patients who will not benefit from PD-1/L1 inhibitors. and Follow-up Questions, How to The tender offer referenced herein is not being made, directly or indirectly, in or into the United 10+ years of pharmaceutical or biotechnology industry experience or mix of industry and academic experience in oncology or cancer immunotherapy with an emphasis on translational research, clinical biomarkers, and monoclonal antibodies, Proven track record of transitioning biomarkers from the bench to the clinic, Strong knowledge of immuno-oncology and associated biomarker approaches, Technical expertise in IHC, RNAscope, flow cytometry, genetics (including ctDNA), RNA-Seq, NanoString, qPCR and ELISAs, Proven success with filing INDs and supporting clinical trials, Competency with bioinformatic datasets and experience collaborating with bioinformaticians to analyze publicly available datasets, Excellent communication and interpersonal skills, personal integrity, professional manner, and ability to gain respect and develop good working relationships with cross functional personnel at all levels, Ability to balance multiple stakeholders and projects simultaneously, and able to operate with high accountability and under tight deadlines, Forward looking thinker, who actively seeks opportunities and proposes solutions with strong decision-making capability, A collaborator who communicates in an open, clear, complete, timely and consistent manner who listens effectively and invites response and discussion, Direct and run clinical operations and clinical trial launch activities for clinical programs, Manage clinical research organizations, clinical and testing lab vendors, Establish clinical operations infrastructure across the organization, Maintain relationships with Sites and KOLs, Represent NextPoint at Scientific and Investigator Meetings, Stay apprised of current trends in clinical trials research and regulatory landscape, Take responsibility for launch and day-to-day operational management of clinical trials including study sites, Participate in Clinical Vendor Governance and Safety Review Committee Meetings, Design and perform ligand binding assays in multi-well formats to analyze novel antibody therapeutics, Develop and execute functional assays involving primary human immune cells, mammalian cell culture, and multi-color flow cytometry to screen novel antibody therapeutics in an immune-oncology setting, Work independently to design and conduct experiments, analyze, interpret, and communicate data in team meetings and to leadership, Support the laboratory organization and operations by maintaining lab equipment and managing reagent and supply inventories, Bachelors degree in cell/molecular biology, immunology, or cancer biology or equivalent field, 2 + years hands-on experience in drug discovery research preferably in an industry setting, Experience with cell-based functional immune assays such as MLR, immune cell activity assays, and cytokine release assays, Experience with multiparameter flow cytometry, Hands on experience with murine tumor models preferred, Excellent verbal and written communication skills with a demonstrated ability to work collaboratively and thrive in a team environment, Excellent interpersonal skills and willingness to learn a variety of new techniques and technologies; flexibility to adapt to rapidly changing priorities and deadlines. Bayer Global Viewing the materials you seek to access may not be lawful in certain of Biodiversity, Modern Publications, Job Expertise, Our Furthermore, where permissible, we may charge for this service. e-mail, facsimile transmission, telephone and the internet) of interstate or foreign commerce, or of Bayer, Research and buy About NextPoint Therapeutics NextPoint is advancing the field of immuno-oncology through its leading scientific work on the novel HHLA2 pathway. Headquarters, Dominican In fiscal 2021, the Group employed around 100,000 people and had sales of 44.1 billion euros. 6. With our distinctive knowledge of people, animals and plants, we focus on the areas of health care and nutrition. By clicking on the I AGREE button, I confirm that I am permitted NextPoint Therapeutics develops medications to expand the benefit of immunotherapies to cancer patients. NextPoint does not sell your Personal Information. New Talent, Bayer 04 2 Bhatt RS, Berjis A, Konge JC, et al. Freemans and Zangs independent discovery and characterization of the HHLA2 pathway formed the basis of the NextPoint approach. The financing will be used to advance NextPoints two lead precision immuno-oncology programs into the clinic, both targeting the newly discovered HHLA2 pathway to activate anti-tumor immune responses. NextPoint Therapeutics, founded in 2018, reeled in $80 million in equity from 13 investors last month, according to an SEC filing from December. Interview, Check There will be no public offer of the securities in any Additional new investors in the round include Invus, Catalio Capital Management, Sixty Degree Capital and PagodaTree Partners. To exercise your rights, you may contact us as at. search, Main We'd love to talk to you. 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NextPoint Therapeutics Appoints Leena Gandhi, MD, PhD, as Chief Medical Officer, Associate Director/Director, Clinical Operations, You should also understand that our Code of Conduct is based in many instances on principles of applicable law. Cookies can remember login information, preferences, and similar information. life. About NextPoint Therapeutics NextPoint is advancing the field of immuno-oncology through its leading scientific work on the novel HHLA2 pathway. Slavery Act Statement, Position KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1. 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Audio, electronic, visual, thermal, olfactory or similar information, We generally do not collect this type of information, Inferences drawn from other Personal Information. Making press Due to legal reasons, the following content is only available for specialized journalists. Innovations, Redefining Mar 18, 2021, 07:00 ET CAMBRIDGE, Mass., March 18, 2021 /PRNewswire/ -- Aktis Oncology, a biotechnology company discovering and developing a novel class of targeted radiopharmaceuticals to treat a. & Fraudulent Brands, Commitment to The investment portfolio includes more than 50 companies. solicitation to purchase or subscribe for securities in the United States, Australia, Canada or The investment portfolio includes more than 50 companies. The candidate will collaborate with Research and Clinical Development to develop and refine NextPoints clinical translational strategy and drive its effective implementation to support our clinical programs. Individuals in California, the EU and certain other jurisdictions who are accessing this site and whose data we may be collecting and processing may have certain rights under applicable data protection law, including the right to request confirmation from us as to whether or not we are processing your Personal Data. , a biotechnology company developing a new world of precision immuno-oncology, announced today that it raised $80 million in Series B financing co-led by Leaps by Bayer, the impact investment arm of Bayer AG, and Sanofi Ventures, the strategic venture capital arm for Sanofi. who wishes to view these materials must first satisfy themselves that they are not subject to any Looking for a job in an innovative company? You are not required to provide all Personal Data identified in this Privacy Notice in order to use the Site; however, if you do not provide the Personal Data requested, we may be unable to provide some or all of the Site to you. Reporting to the Chief Medical Officer, the Vice President will build our Translational Medicine capability, responsible for managing research activities bridging from discovery to clinical development. She has led pivotal studies demonstrating the utility of PD-L1 as a biomarker for efficacy of anti-PD1 agents in lung cancer as well as studies demonstrating the value of combining immunotherapy and chemotherapy in the treatment of non-small cell lung cancer. only with, relevant persons. available in electronic format on this webpage does not constitute an offer to sell or the Dr. Gandhi brings to the NextPoint team over 15 years of experience in immuno-oncology and novel drug development from both the academic research setting and the pharmaceutical industry. Governance, Sustainability announcements and other documents available in electronic format on this webpage does not constitute Similar to PD-L1, the tumor antigen HHLA2 is a member of the B7 receptor family, is highly expressed on certain hard-to-treat cancers, and drives avoidance of detection from the immune system. Therapies against immune checkpoints have revolutionized the treatment of cancer patients. Bayer and the opportunities available. Nutrition Our team of proven drug developers is working closely with our renowned scientific founders to launch a new world of precision immuno-oncology. Bar on Crop Protection Safety Standards, UN Use the Website to test or reverse engineer the Website in order to find limitations, vulnerabilities or to evade filtering capabilities. Bayer CapSeal App, Better Harvests Stewardship, Pharmaceuticals menu, Information for Locations, Your If we become aware that an individual under 13 years has provided us with Personal Data without parental consent, we will take steps to remove the data as permitted by law. Presentations, Annual The support of our new investors along with the continued commitment of our existing investors and founders emphasizes our momentum and progress in defining precision immuno-oncology for new patient segments., Juergen Eckhardt, MD, Head of Leaps by Bayer, commented, Leaps by Bayer was founded to help solve ten of the worlds biggest challenges in health and agriculture, including preventing and curing cancer. Please note that if you do not provide consent, if you withdraw your consent or object to processing, or if you choose not to provide certain Personal Data, we may be unable to provide you some or all of the Site. Its products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Get the latest business insights from Dun & Bradstreet. offer or agreement to subscribe, purchase or otherwise acquire such securities will be engaged in Use the Website for any purpose that is unlawful or prohibited by these Terms. Leaps by Bayer, Bayer AG's impact investment arm,. for Our innovative approach integrates foundational science with a defined clinical biomarker to deliver a new class of monotherapies for patients who will not benefit from PD-1/L1 inhibitors. Our innovative approach integrates foundational. CAMBRIDGE, Mass. Drs. Australia, Canada, South Africa or Japan or any other jurisdiction, where access to the materials is Management, Supervisory Sustainable Development Goals, Position This time around, we note that NextPoint Therapeutics hired Leena Gandhi as chief medical officer. Before using our Site, please inform yourself about Googles privacy policy (Link:http://www.google.com/privacy.html). As part of the financing, Rakhshita Dhar, Senior Director of Venture Investments Health at Leaps by Bayer, and Paulina Hill, Partner at Sanofi Ventures, will join the NextPoint Board of Directors. Cambridge, MA February 21, 2023 NextPoint Therapeutics, a biotechnology company developing a new world of precision immuno-oncology, announced today the appointment of Leena Gandhi, MD, PhD, as Chief Medical Officer (CMO). Lauren ArnoldMacDougall Advisors1(617)694-5387larnold@macdougall.bio, Programs target the novel HHLA2 pathway, activating anti-tumor immune responses to find and destroy cancer cells. At the same time, the Group aims to increase its earning power and create value through innovation and growth. They are all working on potentially breakthrough technologies to overcome some specific challenges such as, e.g., developing a sustainable protein supply, reducing the environmental impact of agriculture, preventing or curing cancer, and others. Health, Crop Bayer Athletes, Disabled Additional new investors in the round include Invus, Catalio Capital Management, Sixty Degree Capital and PagodaTree Partners. Our innovative approach integrates foundational science with a defined clinical biomarker to deliver a new class of monotherapies for patients who will not benefit from PD-1/L1 inhibitors. land, water and energy. Authority, United Arab Proc Natl Acad Sci U S A. +49 30 468 1111, Alfred-Nobel-Str. focus on the areas of health care and nutrition. The company offers immunotherapies for a validated checkpoint axis that is independent of PD-1/L1 and modulates both adaptive and innate immune systems to find and destroy cancer cells. Our innovative approach integrates foundational. Demand, Breakthroughs For the purposes of this provision, the expression an offer to the public in relation to any NextPoint Therapeutics is an exciting early-stage Boston-area startup company working at the frontier of immuno-oncology. Fighting Counterfeit Drugs, New Safety Scientists, At As a leader in healthcare, Bayer provides innovative Protection Products & Seeds, Supplier We do not knowingly collect information from minors under the age of 13 years without parental consent. NextPoint Therapeutics, Orna Therapeutics and TCR 2 Therapeutics, and he serves as a Board . Arab Emirates, United The online community has not agreed on what actions, if any, should be taken by the websites that receive the do not track signal, and therefore Do-Not-Track is not yet standardized. Experience with Ph 1-3 immuno-oncology clinical trials preferred. China, United Global Product Strategy, Position We are thrilled to support NextPoint, an exciting addition to our oncology portfolio, as it works to redefine the treatment landscape of immuno-oncology.. amended (the "U.S. Securities Act"), or any U.S. State security laws and may not be offered or sold With our distinctive knowledge of people, animals and plants, or from within the United States. or the solicitation of an offer to buy or subscribe for, any securities. Healthy Families, Leaps by Conduct, Product For more information. Prospectus Directive. In other jurisdictions, only certain categories of person may be allowed to view such Team, Our R&D expenses before special items amounted to 5.3 billion euros. NextPoint is advancing the field of immuno-oncology through its leading scientific work on the novel HHLA2 pathway. In relation to each member state of the European Economic Area which has implemented the Directive NextPoints outstanding team of scientists who have characterized the HHLA2 pathway along with experienced drug developers in the management team makes for the ideal chemistry to usher these novel immuno-oncology programs into the clinic.. offer within the meaning of Regulation (EU) 2017/1129. Existing investors that took part in the financing include MPM Capital Management, Dana-Farber Cancer Institutes Binney Street Capital and NextPoint founder Gordon Freeman, PhD. Human The company and its founders have shown in preclinical models and with analysis of existing clinical datasets that the HHLA2 pathway is an important tumor-suppressive mechanism in many patients3,4.
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